Beta-Catenin Plasma Test: Liver Fibrosis Degree Assessment in Chronic Hepatitis B Patients

Liver fibrosis caused by chronic hepatitis B infection leads to significant mortality and morbidity. Monitoring evaluation of liver progression depend on the ability detect fibrosis. biopsy as a gold standard for is an invasive technique, while Fibroscan ® with transient elastography non-invasive technique has limitation. Therefore, biomarker needed Beta-catenin multifunctional protein, which Wnt-regulated transcription factor resides in hepatocytes. Hepatitis virus activates Wnt/beta-catenin affects expression target genes This study aimed analyze diagnostic performance plasma beta-catenin levels using reference assess degree patients infection. was observational analytic cross-sectional design. The analysis performed 70 between December 2020 January 2021 at Dr. Moewardi Hospital, Surakarta. ROC used determine cut-off point. best AUC point chosen 2x2 test table. 73.132 pg/mL 0.793 (CI 95%: 0.681-0.906; p<0.001), indicating that results were statistically p<0.05. Sensitivity 74.3%; specificity 71.4%; PPV 72.2%; NPV 73.5%; LR (+) 2.6; (-) 0.36 obtained. level <73.132 pg/mL. A total 26 subjects risk >8 kPa. Plasma had moderate marker.